Tetramers and/or their derivatives are provided for research purposes only. Containing mutations in the MHC α3 domain that ablate CD8 binding; can be used to quantitate and to sort CD8-independent T ...

The CD8-mediated binding can usually be blocked by inclusion of ... Prepare 2x staining cocktail containing all of your labeled reagents at the right titer. The suggested titer for the MHC tetramer ...

They may increase markers like MHC class I, which help alert CD8 T cells, while also boosting levels of HLA-E—a molecule that acts like a "do not attack" sign to immune cells. This back-and ...

Concurrently, SABER activates STING to increase expression of co-stimulatory molecules, resulting in increased activation of CD8 + T cells ... to be loaded onto MHC-I molecules in the ER.

Following allorecognition, CD4 + and CD8 + T cells become activated ... the direct pathway (intact donor MHC molecules displayed on donor antigen-presenting cells [APCs]) and the indirect pathway ...

[14,15] The T-cell receptor on both CD4+ and CD8+ T cells participates in signal transduction during antigen recognition. CD4+ cells, which recognize antigens bound to MHC class II molecules on ...