Rett syndrome is caused by mutations of the MECP2 gene located on the X chromosome. Children with Rett initially show typical ...

The neurodevelopmental disorder Rett syndrome involves mutations in the transcriptional repressor MECP2. Two groups now show a role for MECP2 in postmitotic mouse neurons. You have full access to ...

The resulting discord in gene expression leads to Rett syndrome. "In the current study, our goal was to better understand the molecular changes that occur upon loss of MeCP2 function. Previous ...

Rett syndrome is a devastating neurological disorder caused mainly by mutations in the MECP2 gene found on the X chromosome. The disease causes deficits in brain function that lead to behavioural ...

Rett syndrome is a sporadic disorder (except ... About 90% of cases involve a mutation in the methyl-CpG binding protein 2 gene (MECP2). The role of this gene in the pathogenesis of this enigmatic ...

which in turn causes only a partial decrease of the vital MECP2 protein. (Most Rett cases see a full mutation of the gene on the X-chromosome, which is why the illness generally afflicts girls and ...

Rett syndrome is a developmental disorder that is the leading cause of severe intellectual disability in females. MECP2 mutations are the major genetic mutation associated with Rett syndrome.

continues to study an anomaly in Henry’s case (unlike in most Rett cases, he appears to have only a partial mutation of the MECP2 gene on his x-chromosome), and his parents hope that she will be ...

Rett syndrome is a devastating neurological disorder caused mainly by mutations in the MECP2 gene found on the X chromosome. The disease causes deficits in brain function that lead to behavioural ...

but too much MECP2 protein can cause challenges similar to Rett syndrome, and a successful treatment may be more than a decade away. In the meantime, intensive early therapy may help to delay the ...

Alteration in the expression of methyl-CpG-binding protein 2 (MeCP2) has been linked to a number of neurological disorders, including Rett syndrome (RTT). A recent modifier screen in flies has ...