This disables the production of MeCP2 protein in all cells, as males have only one X chromosome. In humans with Rett, this ...

The team focused on engineering the parasites to deliver the MeCP2 protein, which is already seen as a promising treatment for Rett syndrome, a debilitating neurological disorder caused by ...

Alteration in the expression of methyl-CpG-binding protein 2 (MeCP2) has been linked to a number of neurological disorders, including Rett syndrome (RTT). A recent modifier screen in flies has ...

which in turn causes only a partial decrease of the vital MECP2 protein. (Most Rett cases see a full mutation of the gene on the X-chromosome, which is why the illness generally afflicts girls and ...

MECP2 mutations are the major genetic mutation associated with Rett syndrome. Diagnosis is made via observable features, which include regression of developmental features, including language and ...

The neurodevelopmental disorder Rett syndrome involves mutations in the transcriptional repressor MECP2. Two groups now show a role for MECP2 in postmitotic mouse neurons. You have full access to ...

Bracha and her colleagues introduced the engineered parasite to human brain cells in vitro and found that the GRA16-MeCP2 protein bound to methylated DNA in a manner similar to normal MeCP2.

In 1999, we discovered that Rett syndrome is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Located on the X chromosome, MECP2 encodes a protein that binds methylated ...

As RTT is caused by mutations in the gene Methyl-CpG-binding protein 2 (MECP2), we utilize many animal models lacking this gene to study RTT. Our lab uses an extensive combination of experimental ...