The study, published in Communications Biology, analyzed the cerebral cortices of male and female mice with and without MECP2 ...

Two groups now show a role for MECP2 in postmitotic mouse neurons. You have full access to this article via your institution. The work of Bird and Jaenisch provide the means to answer many ...

"We conditionally deleted Mecp2 in adult mice, which reproduces all the characteristic deficits and premature death observed in male animals in which the Mecp2 is deleted from conception.

The syndrome is caused by a mutation of the MECP2 gene, which is located on the X chromosome. Patients have abnormal neuronal morphology, but the neurons do not die. Investigations in mice have ...

MECP2 mutations are the major genetic mutation associated with Rett syndrome. Diagnosis is made via observable features, which include regression of developmental features, including language and ...

Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in neurodevelopment, and how ...