Rett syndrome is caused by mutations of the MECP2 gene located on the X chromosome. Children with Rett initially show typical ...

As RTT patients are mosaic with respect to MeCP2 expression owing to random X-chromosome inactivation, gene therapy-based strategies for treatment of RTT that involve increasing MeCP2 expression ...

MECP2 mutations are the major genetic mutation associated with Rett syndrome. Diagnosis is made via observable features, which include regression of developmental features, including language and ...

Rett syndrome is a devastating neurological disorder caused mainly by mutations in the MECP2 gene found on the X chromosome. The disease causes deficits in brain function that lead to behavioural ...

This partnership aims to advance innovative genetic medicine approaches for the treatment of Rett Syndrome, a rare genetic neurological disorder caused by random mutations in the MECP2 gene on the ...

The syndrome is caused by a mutation of the MECP2 gene, which is located on the X chromosome. Patients have abnormal neuronal morphology, but the neurons do not die. Investigations in mice have ...

In 1999, we discovered that Rett syndrome is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Located on the X chromosome, MECP2 encodes a protein that binds methylated ...