This disables the production of MeCP2 protein in all cells, as males have only one X chromosome. In humans with Rett, this ...

Alteration in the expression of methyl-CpG-binding protein 2 (MeCP2) has been linked to a number of neurological disorders, including Rett syndrome (RTT). A recent modifier screen in flies has ...

Precisely for being a master controller, it has been difficult to decipher how exactly MeCP2 loss of function leads to the ...

Of the many therapeutic proteins they engineered into Toxoplasma, only a few—including MeCP2 and transcription factor EB, which may help counteract neurodegeneration—successfully hitched a ride with ...

The syndrome is caused by a mutation of the MECP2 gene, which is located on the X chromosome. Patients have abnormal neuronal morphology, but the neurons do not die. Investigations in mice have ...

Neurogene (NGNE) announced a peer-reviewed publication on its EXACT transgene regulation technology. The preclinical ...

Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in neurodevelopment, and how ...