The US Department of Health and Human Services has launched a "massive testing and research effort" that will determine "what has caused the autism epidemic" by September, its Secretary Robert F.

Alteration in the expression of methyl-CpG-binding protein 2 (MeCP2) has been linked to a number of neurological disorders, including Rett syndrome (RTT). A recent modifier screen in flies has ...

MECP2 mutations are the major genetic mutation associated with Rett syndrome. Diagnosis is made via observable features, which include regression of developmental features, including language and ...

We and others have discovered that MECP2 mutations cause a broad spectrum of phenotypes in both females and males. Females may present with isolated mental retardation, autism, or milder forms of Rett ...

our lab is interested in Rett syndrome (RTT), a rare autism spectrum disorder (ASD) primarily affecting females, which results in motor abnormalities and social deficits. As RTT is caused by mutations ...

Around 80% of autism cases can be linked to inherited gene mutations. Changes in certain genes like MECP2 have been found to alter brain development, but the evidence that specific changes are ...