However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...

My colleagues and I are studying two other closely related proteins that regulate p53 by marking it for destruction when it's ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

Furthermore, Mdm2 not only functions as an E3 ligase in the degradation of p53, but is also involved in exporting p53 out of the nucleus before its degradation.