Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to ...

Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how human bodies detect and respond to viruses and viral replication.

Several 'sensors' of RNA, including Toll-like receptors (TLRs) and the RNA helicases RIG-I and Mda5, have been shown to be essential for innate immune responses to many types of pathogens.

It is triggered by antibodies that attack an enzyme called MDA5 (melanoma differentiation-associated protein 5) – an RNA receptor that is key to recognising the SARS-CoV-2 virus, IFL Science ...

A recent eBioMedicine study identifies shared immunopathology between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and melanoma differentiation-associated protein-5 (MDA5 ...