Much of our early work focused on the MALAT1 locus, which is over-expressed in many human cancers and produces a long nuclear-retained noncoding RNA as well as a tRNA-like small RNA known as mascRNA, ...

One such lncRNA of interest is MALAT1, abbreviated for metastasis-associated lung adenocarcinoma transcript 1. Initially noted for its impact on gene expression in non-small-cell lung cancer cells ...

Diederichs, his fellow postdoc Ping Ji, and their colleagues dubbed this RNA transcript, which was more than 8,000 nucleotides long, MALAT-1 (metastasis-associated in lung adenocarcinoma transcript 1, ...