Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

A new study shows that dysfunction of lysosomes can cause leakage of toxic substances within brain cells, contributing to ...

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Several of the genes associated with Parkinson's disease are involved in the regulation of lysosomes. These cellular organelles serve as the garbage cans of the cell, accumulating and breaking ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Whether they know it or not, everyone recycles. This is because every one of the billions of cells that make up you and I constantly recycle biomaterials using specialized tiny organelles called ...