Deficiency of ADAMTS13 plays a critical role in platelet accumulation in PA-ILI, suggesting that ADAMTS13 could be a potential therapeutic target for this condition.

or severe fever with thrombocytopenia syndrome (SFTS), she was later diagnosed with TTP based on the presence of schistocytes in peripheral blood smears and significantly low ADAMTS13 levels.

"Given these findings and the results reported here, the overall immunogenic potential for ADAMTS13 replacement in patients with congenital TTP appears to be low." No other safety concerns emerged ...

At the moment, treatment is the administration of fresh plasma in order to indirectly replenish ADAMTS13 levels in the body and address the symptoms of cTTP, which include haemolytic anaemia, low ...