An estimated 1 in 3,000 individuals may carry a genetic variant tied to pneumothorax and RCC—approximately 100 times more ...

One of the key experimental approaches to elucidate the function of a gene in vivo is the selective ablation of its expression or activity by one of several loss-of-function (LOF) approaches.

Credit: deCODE genetics To harness the information contained in rare loss-of-function (LOF) variants, the scientists performed a variant burden analysis for bipolar disorder using gene-based ...

To harness the information contained in rare loss-of-function (LOF) variants, the scientists performed a variant burden analysis for bipolar disorder using gene-based aggregation of LOF variants ...

To harness the information contained in rare loss-of-function (LOF) variants, the scientists performed a variant burden analysis for bipolar disorder using gene-based aggregation of LOF variants in ...