Scientists at the University of Michigan Rogel Cancer Center have found a promising new way to fight one of the most ...

Such changes are induced by the aberrant activity of enzymes that chemically modify DNA and its histone protein packaging to regulate gene expression. One such "epigenetic" enzyme, LSD1—discovered in ...

Suppression of LSD1 function (LSD1-KD) inhibits glucose (sugar) uptake into cells (left) and significantly reduces the number of hemoglobin-positive cells (right).

LSD1 inhibition has started to gather momentum as a target in oncology with several candidates in the clinic, particularly for haematological cancers, as the protein is thought to regulate gene ...

A novel drug combination targeting LSD1 and GSK3 shows promise in treating acute myeloid leukemia by promoting cell ...

Iadademstat, a selective LSD1 inhibitor, is being tested with immune checkpoint inhibitors for extensive-stage SCLC in a phase 1/2 trial. The trial, led by the National Cancer Institute, evaluates ...

The patent, titled “Methods of treating Attention Deficit Hyperactivity Disorder using KDM1A inhibitors such as the compound vafidemstat”, covers the use Oryzon’s LSD1 inhibitor, vafidemstat ...

Such changes are induced by the aberrant activity of enzymes that chemically modify DNA and its histone protein packaging to regulate gene expression. One such “epigenetic” enzyme, LSD1—discovered in ...