Mutation and altered expression of components of the canonical Wnt pathway are linked to human diseases other than cancer (reviewed in Refs 141, 218): Loss-of-function mutations of LRP5 are not ...

Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...