Recent experiments performed in mice revealed that the Lrp5 effect on bone formation occurs via gut-derived serotonin. If this finding to be extrapolated to humans, inhibition of the gut-derived ...

At least 14 receptors for serotonin have been cloned and are found in multiple tissues, although only three are expressed in bone 4. These findings suggest that Lrp5-related bone diseases might ...

218): Loss-of-function mutations of LRP5 are not only linked to low bone mass but also to eye defects, such as familial exudative vitreoretinopathy (FEVR). Many cases of FEVR are linked to loss-of ...