Activating the LKB1-AMPK-mTOR pathway could protect tumor cells from anoikis, which is a form of cell death that occurs when cells detach from the basement membrane. A-769662 is an AMPK agonist ...
The LKB1-AMPK-mTOR pathway suppresses tumor development. LKB1-AMPK disrupt mTOR activity leading to decreased survival and proliferation while increasing autophagy. Pharmacological compounds that ...
The alteration frequency including mutations, structural variants, amplifications, deep deletions, and multiple alterations of LKB1 in tumors. Listed in descending prevalence are LKB1 genetic ...
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