monocytogenes challenge. The functional relationship of L-Myc to other Myc factors has remained uncertain 4. We show that L-Myc is selectively expressed in DCs, maintained during inflammation ...

The Myc family of oncoproteins (c-Myc, N-Myc, and L-Myc) regulate critical pathways that contribute to tumors; c-Myc expression, which is activated in human Burkitt lymphoma, is sufficient to ...

Genes in the Myc family, especially L-Myc, are often amplified in SCLC, which implies they may influence cancer development or recurrence. The team’s findings suggest that treatments that target a ...

MRT-2359 had limited activity in low L-Myc or N-Myc NSCLC models, further corroborating the selective vulnerability of Myc-driven tumors to GSPT1 degradation. Analyses of real-world data indicate ...

Numerous instances of tumor regressions were observed in these models with MRT-2359 when dosed orally daily or intermittently A causal link was established in vitro between N- and L-MYC expression ...

The MYC transcription factors (c‑MYC, L-MYC and N-MYC) are well-established drivers of human cancers that maintain high levels of protein translation, which is critical for uncontrolled cell ...

Image Caption: The Myc family of transcription factors, including Myc, N-Myc, and L-Myc, bind DNA at specific sequences and regulate gene expression by binding to enhancer-box (E-Box) sequences ...

U.S. Food and Drug Administration (FDA) granted Fast Track designation to MRT-2359 in January for the treatment of patients with previously treated, metastatic NSCLC with L-MYC or N-MYC expression.

MYC is dysregulated in nearly 70% of human cancers, where it influences a vast network of biological processes including cell cycle control, metabolism, apoptosis, angiogenesis, and immune evasion.

namely c-Myc, l-Myc or n-Myc. Synthetic lethality is the interaction between two genes that causes cell death when both are inactivated. In cancer cells, one of the genes is inactivated by a ...

Dr. James L. Gulley is co-chair of the 34th EORTC-NCI ... U.S., and was not involved in the research. He says that "MYC plays an important role in many cell-signaling pathways that promote a ...