Non-ATP competitive inhibition of these three kinases offers an alternative drug design strategy. Inhibitors that target binding pockets that affect kinase activation loop conformation ...

1). The phosphorylation of the biotin-tagged generic peptide is initiated by the addition of ATP in the presence of the tyrosine kinase (step 1) and stopped by the addition of a mix containing the ...

KdELECT® Kinase Assay – Broadest Dynamic Range KINOMEscan assays do not require ATP and therefore report true thermodynamic interaction affinities, as opposed to IC50 values, which can depend on the ...

Nowadays, the prevalence of sedentary lifestyles and high-caloric diets leads to an imbalance between energy intake and spending. Hence, in the last decades, researchers have observed a significant ...