When the researchers monitored the metabolic rates of the Klf15 knockout mice they observed that these mice burned more energy compared to controls. “Rather than targeting the stem cells, targeting ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...