Over a decade ago, a Phase I clinical trial of irinotecan found an inverse relationship between SN-38 glucuronidation rates and frequency of diarrhea. [6] This led to the hypothesis that ...

Final results from the only European trial demonstrated a 1.4-month median survival improvement with irinotecan compared with etoposide (8.5 versus 7.1 months, P = 0.02) in patients with SCLC. 4 ...

Haller et al. demonstrated that irinotecan plus oxaliplatin (IROX) is more efficacious than irinotecan alone after fluoropyrimidine failure in advanced colorectal cancer. IROX does not change ...

Artios Pharma Limited (“Artios”), a clinical-stage biotech company led by pioneers of DNA damage response (“DDR”) drug development, today announced that the company’s abstract featuring clinical trial ...

Find all the commercial and brand names of generic drug called Irinotecan. This is an invaluable reference resource for healthcare professionals, patients, caregivers and anyone in need of ...

NICE is unable to make a recommendation on pegylated liposomal irinotecan plus oxaliplatin, 5-fluorouracil and leucovorin for untreated metastatic pancreatic cancer in adults. This is because the ...

In this particular study, treatment-related mortality occurred in 5.3% and 1.6% of patients receiving irinotecan weekly and every three weeks, respectively. Determining a patient's genotype status ...