If that holds true, “It’s just injection of a cytokine which can be done in patients pretty easily,” he said. More work is required to establish this immune crosstalk in humans, agreed Chang. But ...

Figure 1: Upregulated cellular responses to human IL4 after transfection with the Ile50 variant of IL4Rα compared with the Val50 variant a, Cell proliferation by MTT dye assay.

In 2021, the platform achieved an Authorization to Operate with Conditions (ATO-C) from the Department of the Air Force for conducting IL4 meetings.

In TTP-deficient basophils, the stability of mRNAs encoding key inflammatory molecules, including Il4, Il13, Areg, Ccl3, Cxcl2, and Ptgs2, was prolonged, leading to excessive cytokine and ...