This model was generated by backcrossing an IL2rg (common gamma) knockout model to a RAG2 (recombinase activating gene) knockout model. The resulting mouse lacks various cytokines including IL-2, IL-4 ...

No derivatives or adaptations of the work are permitted. Comparison of the EFS-IL2RG.wt and EFS-IL2RG.co vectors in human ED7R cells and the bone marrow stem cells.

With a deep pipeline of cell and gene therapies (Fig ... caused by mutations of interleukin-2 receptor subunit gamma (IL2RG). XSCID predominantly affects males, and without treatment, XSCID ...