Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism ...

(A–H) Western blots and quantitative PCR were performed to analyze IRF8 levels in the livers of C57BL/6J male mice fed with HFD or CD (A, B) (n = 5 biologically independent mice), lean or ob/ob ...

The Irf8 floxed targeted mutated mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated.