(J, K) Protein levels (J) and relative mRNA expression (K) of Pparγ and its target genes were determined in MPHs transfected with si-NC + Vector, si-IRF8 + Vector, si-NC + BMAL1 OE, and si-IRF8 ...

Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism ...

(A–H) Western blots and quantitative PCR were performed to analyze IRF8 levels in the livers of C57BL/6J male mice fed with HFD or CD (A, B) (n = 5 biologically independent mice), lean or ob/ob ...

We further showed that IGF-1 stimulation of MM cells leads to enhanced expression of IRF4, a known ‘addictive’ factor for MM. This upregulation of IRF4 expression by IGF-1 treatment of MM ...

The Irf8 floxed mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the identification of IRF8 ...