as a negative regulator of the type I interferon signaling pathway, and that SMYD3 directly catalyzes the dimethylation of IRF3 at lysine 39. Researchers first discovered that SMYD3 negatively ...

Unraveling the pathway's role in immune system activation ... of essential kinases and transcription factors, such as TBK1 and IRF3, which drive the transcription of genes responsible for the ...

As they dissected the signaling cascade of the MAVS pathway, Chen’s interest naturally turned to ... the cytoplasm and applied it to a second set of cells, where they tracked IRF3 activation as a sign ...