A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighbouring and immune cells by secondary ...

More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...