Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while ...

STING and IRF3 can detect DNA outside of these compartments, and report it to the neighbouring and immune cells by secondary messengers, including cGAMP and Interferon. As such, this system ...

Interferon gamma (IFN-γ) is a cytokine that induces a series of immune responses against viruses and tumors. The pro-apoptotic, anti-tumor and anti-proliferative actions of the cells are ...