and mitochondria (mitochondrial DNA). A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring ...

He obliterated STING in a murine cell line and transfected the cells with different types of DNA. The team then collected the cytoplasm and applied it to a second set of cells, where they tracked IRF3 ...