The therapy has a direct cytotoxic effect on tumor cells that express IL-2 receptors and depletes host Tregs to enhance ...

and high-affinity IL-2 receptors, and they are expressed individually and variably on distinct cell types. PEG modification, IL-2 mutant design, fusion Fc, bispecific antibody design, combination ...

Anti-CD25 mAbs that selectively block IL-2 receptors (IL-2 receptor antagonists) on activated T helper cells are being used prophylactically as complementary immunosuppression with CsA and ...

Investigative therapies to treat moderate to severe plaque psoriasis in clinical trials include several orally administered ...

Researchers have previously demonstrated antidepressant-like effects of delta opioid receptor ... potential of DOP agonists. Additionally, KNT-127's application to isolated IL-PFC brain tissue ...