Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to a high risk of bowel cancer, also a greatly increased risk of duodenal cancer.

In patients with psoriasis or ankylosing spondylitis, the use of interleukin (IL)-17A inhibitors, particularly secukinumab, was associated with an increased risk for inflammatory bowel disease ...

IL-17A and IL-17F affect the pathogenesis of Crohn's disease and ulcerative colitis, although their precise role in the development of these disorders requires further characterization.