Familial adenomatous polyposis (FAP) is a hereditary disease which, in addition to a high risk of bowel cancer, also a ...

The risk for inflammatory bowel disease is higher in patients with psoriasis or ankylosing spondylitis using IL-17A inhibitors than in those using apremilast, necessitating careful patient monitoring.

Patients with psoriatic arthritis exhibit high levels of both IL-17A and IL-17F cytokines in the synovium. Bimekizumab, a biologic that targets both IL-17A and IL-17F, was recently approved for the ...

Get Instant Summarized Text (Gist) A high-salt diet induces depression-like symptoms in mice by increasing the production of the protein IL-17A, which is linked to depression in humans. Gamma ...

and subsequently produce IL-22 and six different IL-17 cytokines (IL-17A–F). The increase in the IL-17 cytokines induces the keratinocyte response, the end result being decreased maturation and ...

Another promising candidate, ORKA-002, which targets IL-17A/F, is set to enter Phase 1 trials in Q3 2025, with preclinical data to be presented at the 2025 AAD Annual Meeting. Oruka successfully ...

but Hitoshi Kohsaka and colleagues have now shown that mice lacking IL-17A can still develop polymyositis. The investigators suggest that IL-6 might be the culprit and could, therefore ...