GlaxoSmithKline's IkappaB kinase 2 (IKK-2) inhibitor, TCPA-1 has recently been developed and has shown considerable promise in early stage development. DailyUpdates 15th September, 2004: An estimated ...

F. & Verma, I. M. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284, 321–325 (1999). Li, Z. W. et al. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear ...

Figure 2: The TAK1 complex is both sufficient and necessary to activate IKK in conjunction with TRAF6 and Ubc13–Uev1A. To determine whether the TAK1 complex is essential for IKK activation by ...