Our study has identified a novel mechanism by which an acquired somatic mutation acts ... For those GBM patients not fortunate enough to have acquired the spontaneous IDH1 mutation in their tumour, ...

The US regulator has approved Tibsovo (ivosidenib) in combination with Bristol-Myers Squibb's chemotherapy Vidaza (azacitidine) as a first-line therapy for IDH1-mutated acute myeloid leukaemia ...