Gliomas arise from glial cells, which protect and support ... "So, there's a great need to understand these tumors better." In IDH-driven gliomas, the mutated IDH enzyme fosters the addition ...

Multiple types of gene changes may cause glial cells to grow into tumors. IDH-mutant gliomas have changes in the IDH1 or IDH2 gene. These genes instruct your body to produce isocitrate ...

As an oncometabolite, R-2-HG induces malignant transformation of glial progenitor cells ... in mIDH1 liver and brain tumors. Inhibition of mutant IDH drives DNA demethylation, derepressing the ...

tells SurvivorNet it’s a “game-changer” for patients with IDH-mutated, grade two glioma. Glioma is a primary brain tumor that originates from the glial cells present in the central nervous ...

HealthDay News — For patients with diffuse gliomas, tumor-related epilepsy (TRE) is not a strong prognostic factor, according to a study published in the May issue of Brain and Behavior.

A genomewide mutational analysis might pave the way to personalizing brain tumor treatments based on ... in the gene for isocitrate dehydrogenase 1 (IDH1) in 83% of secondary GBMs (arising from ...

IDH inhibitors are now approved by the Food and Drug Administration (FDA) and are available for patients with lower-grade gliomas, offering a therapeutic option with a more manageable side effect ...

Gliomas arise from glial cells, which protect and support a healthy nervous system. A substantial proportion of glioma cases are caused by mutations in IDH (isocitrate dehydrogenase). “Patients ...

Types of gliomas, such as astrocytoma and oligodendroglioma, are types of cancers that originate from the glial cells in ... with gliomas who have IDH mutations, are commonly younger adults. Because ...