There is evidence linking HtrA2 to p53. In particular, HtrA2 may help in determine some of the proapoptotic functions of p53. The proposed mechanism passes through a p53-mediated increase in HtrA2 ...

We report that Cdk5 is the kinase responsible for the phosphorylation of HtrA2 at S400 upon activation of the p38 signalling pathway. The interaction between HtrA2 and Cdk5 can occur both in the ...

Dr Jorg Hartkamp and Dr Stefan Roberts have found that the protease HtrA2 can "clean" cells of the oncogene WT1, which is found at high levels in many leukaemias and solid cancers such as breast ...

Over the last few years we have identified the transcriptional repressor BASP1 and the apoptotic protease HtrA2 as major regulators of WT1 function (see figure 1). Our current studies aim to determine ...

Dr Joerg Hartkamp and Dr Stefan Roberts have found that the protease HtrA2 can “clean” cells of the oncogene WT1, which is found at high levels in many leukaemias and solid cancers such as breast and ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2004 ASCO Annual Meeting. This abstract does not include a full text component.