In this review we provide an overview of the roles of Hsp70 in cancer, spanning the initial observations that the levels of the heat shock protein Hsp70 are elevated in many human tumors ...

Inhibiting the protein Hsp70 rapidly reduces brain levels of tau, a protein associated with Alzheimer's disease when it accumulates as memory-choking tangles. One of the more effective Hsp70 ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Therefore, cells have mechanisms in place to control protein quality. In animal and human cells, chaperones of the Hsp70 ...

Phase 1 open-label trial to evaluate the safety and immunogenicity of PAN-301-1, a novel nanoparticle therapeutic vaccine, in patients with biochemically relapsed prostate cancer. This is an ASCO ...