Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

a model system for studying cell division. They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific ...

With Drosophila as their animal model, McKay and colleagues first determined that the methylation of histone H3 lysine-4 is required for the activation of "master regulator" genes. These genes are ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer. Peter Dempsey, PhD, professor of ...

Prior to this trial, CS014 had positive outcomes in an animal model. Researchers are moving ... one of the phase 1 trial assessing CS014, a histone deacetylase inhibitor that has potential in ...