3 To sequence histone modifications, many researchers are now turning towards cleavage under targets and release using nuclease (CUT&RUN) or cleavage under targets and tagmentation (CUT&Tag) methods.

Histone deacetylases (HDACs ... Figure 1: Effect of HDAC inhibitors on chromatin remodelling and transcription. Figure 3: Schematic of representative HDAC effects in the nucleus and cytoplasm.