Spontaneous loss of hepatitis B e antigen (HBeAg) followed by seroconversion to anti-HBe usually coincides with normalization of serum alanine aminotransferase (ALT) levels, reduction in HBV DNA ...

Natural seroconversion from HBeAg to anti-HBe is associated with sustained remission of hepatitis in about two thirds of patients. Reactivation to HBeAg can occur at any time. Recent follow-up ...