HSV-tk is an enzyme that locally converts orally administered valacyclovir into a toxic metabolite that kills nearby cancer cells. Together, this regimen is designed to induce an individualized ...

Figure 2: FIAU accumulation rates (K i FIAU) demonstrate viral TK activity in HCT8 cells after infection with each of 3 HSV-1 recombinants. Figure 3: Transaxial PET images of viral-treated human ...

Such T cells have been genetically modified by incorporation of a replication-incompetent vector (NIT) for an inactive mutant nerve growth factor receptor (LNGFR) as an immunoselectable surface marker ...