News

Nature13y
Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch
Heat shock protein 27 (Hsp27) is emerging as a promising therapeutic target for treatment of various cancers. Although the role of Hsp27 in protection from stress-induced intrinsic cell death has ...
ascopubs.org1y
Phase I trial of OGX-427, a 2'methoxyethyl antisense oligonucleotide (ASO), against heat shock protein 27 (Hsp27): Final results.
Background: Hsp27 is a chaperone protein that affects multiple pathways implicated in cancer progression and treatment resistance. OGX-427 is a 2nd generation ASO that inhibits Hsp27 expression ...
ascopubs.org10y
Analysis of heat shock protein HSP27 secretion in an ovarian cancer cell model and detection of cell-free HSP27 in patient blood serum sample.
Characterising phenotypically relevant intratumoural heterogeneity in high grade serous ovarian cancer. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not ...