The mechanism is dependent on adaptor protein MyD88-TLR-9 and the immunoglobulin superfamily member RAGE (receptor for advanced glycation end products). In addition, HMGB1 was present in DNA ...

The focus is to to characterize the neuroinflammatory response to surgery and morphine in young and aged rats; and to determine the roles of HMGB1 and microglia in mediating POCD. The guiding ...