Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...

CCR5-tropic virus is the predominant virus encountered, though CXCR4-tropic virus strains are more likely encountered, in patients with advanced HIV disease. Results from Phase III clinical trials ...

CCR5 antagonists only work against CCR5-tropic HIV. The British HIV Association recommends that tropism testing should take place before switching to maraviroc, using a genotypic test. Maraviroc is ...