Current guidelines state that the goal of therapy is to achieve and maintain HIV-1 RNA below detectable levels, with recommendations to switch regimens upon virologic failure based on the adverse ...

Because of improvements in the sensitivity of viral-load assays, it is now possible to detect HIV RNA levels below 50 copies/mL. However, in patients on antiretroviral therapy (ART), the clinical ...

"For instance, uORFs and iORFs can act as regulators, ensuring precise timing and levels of protein ... replication of HIV-1. The researchers demonstrated that this extended RNA fold not only ...

The following is a summary of “Factors influencing virologic control during analytical treatment interruptions in HIV cure ...

The company’s Phase IIb trial found the therapy, N6LS, was able to maintain viral loads below a detectable threshold.

The early results of trials for two injectable, investigational antiretroviral therapies, VH4524184 and VH4011499, have the ...

In trials, 81% of participants taking the regimen achieved HIV RNA suppression, where levels of HIV were low enough to be considered undetectable after six months, with 83% showing continued ...

We cannot yet determine whether the majority of these cells harbor transcriptionally silent HIV, or whether there is continuous low-level expression of viral RNA in all cells. For many reasons it ...

Key findings from the trial include durable viral suppression, with 94% of participants maintaining RNA levels below 50 ...