Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that consists of two proteins — HIF-1α and HIF-1β. HIF-1 activates the transcription of many genes that code for proteins that are ...

HIF-1 is involved in the inflammatory response. Inhibition of HIF-1 in myeloid cells can ameliorate and even prevent inflammation, indicating a new role for HIF modulators. Development of HIF ...

Treatment was according to BCCA guidelines that instituted R-CHOP as the standard therapy for DLBCL as of March 1, 2001 (standard therapy before 2001 was CHOP), as previously described. 15 ...

1 These other mechanisms rely on oxygen-sensing prolyl hydroxylases (PHDs), which hydroxylate prolines in the alpha subunit of the hypoxia-inducible transcription factor (HIF). This transcription ...

They found that low blood sugar, or hypoglycemia, resulted in an accumulation of hypoxia-inducible factor-1⍺ (HIF-1⍺) and HIF-2⍺. Both are transcription factors: proteins that help control ...

AKB-4924 (to be known as GB004) is an investigational hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilizer in development for IBD. Unlike other HIF stabilizers in clinical development ...

ARC-20 is a Phase 1/1b dose-escalation and expansion study ... ORR and mPFS relative to published data from studies with HIF-2a inhibitors to date. At the time of data cut off (DCO, January ...

New research reveals how low blood sugar can damage the retina in diabetes, highlighting potential treatments targeting ...

When overabundant in cells, HIF-2α is associated with increased cancer ... both an immune checkpoint inhibitor (ICI), such as a PD-1 or PD-L1 inhibitor, and an anti-angiogenic therapy.