New research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

The paper Y. Cho et al., “Injury-induced HDAC5 nuclear export is essential for axon regeneration,” Cell, 155:894–908, 2013. To regenerate after injury, a nerve cell must turn on gene programs that ...

Interestingly, HDAC8 is specifically produced in Schwann cells surrounding sensory neurons that transmit information on ...