The high expression levels of HDACs observed particularly in high grade urothelial bladder cancer clearly warrant subsequent studies on the potential use of HDAC inhibitors as a novel therapeutic ...

In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage from the drug combination. In future studies, the team hopes to ...

[91] There are currently no published data on these compounds with respect to prostate cancer. Whether HDAC inhibitors display enough promise to be considered as potential single-agent therapies ...

Epigenetics and Cancer The first human disease to be linked ... Drugs aimed at histone modifications are called histone deacetylase (HDAC) inhibitors. HDACs are enzymes that remove the acetyl ...

Cereno Scientific reported a successful meeting with the FDA on the design of a future clinical trial for its PAH therapy ...

which is often associated with tumor suppressor genes. Propionate, while less studied as an HDAC inhibitor, showed similar chromatin accessibility effects in the study. The localization of SCFA ...

HDAC inhibitors are already on the market for cancer and some other indications – including Duchenne muscular dystrophy. However, the development of selective HDAC6 inhibitors for cancer has ...