It presents a structure–function analysis of four HDAC classes, the NAD +-independent and NAD +-dependent enzymes, subcellular localization, and substrates for deacetylation. Furthermore ...

LBH589 is a novel pan-histone deacetylase (HDAC) inhibitor that has potent antitumor activity in multiple myeloma and other hematological malignancies. However, its impact on the immune system has ...