HDAC inhibitors affect cellular metabolic pathways, and more specifically restore the defective cholesterol metabolism in models of Niemann–Pick type C disease. A link between metabolism and ...

RelB, a component of the nuclear factor-κ B signaling pathway, was the key component regulated by HDAC inhibition in DCs. Together, our preclinical study demonstrates that LBH589 significantly ...

Additionally, the platform supports combination therapies using hedgehog pathway inhibitors alongside HDAC inhibitors to amplify anti-cancer effects. “This new patent for our oncology ...